Figure 2. Defining features of human Trm cells.

Trm cells have a unique profile of transcription factor expression, surface expression of homing receptors and adhesion markers to maintain tissue residency, and a distinct functional profile with increased expression and ability to secrete both pro and anti-inflammatory cytokines. Trm cells also upregulate a number of inhibitory genes and exhibit reduced proliferative turnover compared to circulating memory T cell counterparts.