Table 3.
Standard PAT (N=134) median (IQR) |
PAT+ (N=133) Median (IQR) |
|||
---|---|---|---|---|
| ||||
~15 Weeks | ~35 Weeks | ~15 Weeks | ~35 Weeks | |
Fasting glucose | 80.7 | 78.1 | 81.1 | 77.7 |
(mg/dL) | (76.7, 85.1) | (75.4, 83.2) | (76.0, 85.3) | (73.1, 84.4) |
Fasting insulin | 9.6 | 14.2 | 10.7 | 15.5 |
(μU/mL) | (6.6, 14.8) | (8.8, 19.0) | (7.0, 17.0) | (9.6, 25.0) |
OGIS a | 406.5 ± 68.2 | 388.8 ± 70.4 | 390.9 ± 73.9 | 373.2 ± 80.5 |
Glucose AUC | 15047 | 14488 | 14946 | 14604 |
(mg/dL x 120 min) | (13667, 16295) | (13524, 16389) | (13918, 16269) | (13349, 15798) |
Insulin AUC | 10733 | 13149 | 13109 | 13421* |
(μU/mL x 120 min) | (8212, 15503) | (10625, 17563) | (9333, 19339) | (8848, 19590) |
HOMA-IR | 2.0 | 2.6 | 2.1 | 2.9 |
(1.3, 3.0) | (1.6, 3.7) | (1.5, 3.4) | (1.8, 4.4) | |
Total cholesterol | 158.0 | 205.0 | 160.0 | 198.5 |
(mg/dL) | (142.0, 178.0) | (177.0, 225.0) | (140.0, 186.0) | (179.0, 225.0) |
LDL-cholesterol | ||||
(mg/dL)a | 81.0 ± 23.6 | 103.4 ± 32.4 | 83.34 ± 25.63 | 108.5 ± 36.0 |
HDL-cholesterol | ||||
(mg/dL)a | 63.0 ± 13.7 | 68.0 ± 16.3 | 63.1 ± 14.0 | 65.9 ± 15.7 |
Triglycerides | 75.0 | 145.0 | 76.0 | 143.0 |
(mg/dL) | (60.0, 97.0) | (125.0, 187.0) | (60.0, 98.0) | (122.0, 175.0) |
SBP (mmHg) | 109.0 | 111.5 | 112.0 | 109.7** |
(104.0, 119.0) | (105.0, 120.0) | (105.7, 120.0) | (105.0, 117.0) | |
DBP (mmHg)a | 67.0 ± 8.0 | 69.7 ± 8.9 | 67.2 ± 8.7 | 67.5 ± 8.8 |
OGIS, Oral Glucose Insulin Sensitivity; AUC, area under the curve; HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; LDL, low density lipoprotein; HDL, high density lipoprotein; SBP, systolic blood pressure; DBP, diastolic blood pressure; kg, kilogram SI conversion factors: To convert glucose from mg/dL to mmol/L, multiply by 0.0555; for insulin from μU/mL to pmol/L, multiply by 6.945; for cholesterol from mg/dL to mmol/L, multiply by 0.0259; for triglycerides from mg/dL to mmol/L, multiply value by 0.0113
Data are means ± SD
Change in value during pregnancy significantly different from Standard PAT group, *P =0.01, **P = 0.02