Fig. 1.

Schematic overview of proteins involved in anti-Candida host defense of which genetic variants have been identified to increase susceptibility to either mucosal or systemic Candida infection. Only those proteins, and the context of these proteins within antifungal immunity, are depicted of which genetic variants in the encoding genes are associated with an increased susceptibility to infection. These proteins have diverse functions, ranging from recognition of Candida, cytokine signaling and cellular immunity. TLR, Toll-like receptor; MR, mannose receptor.