. Author manuscript; available in PMC: 2019 Jan 1.

Published in final edited form as: Biochem Pharmacol. 2017 Nov 15;147:141–152. doi: 10.1016/j.bcp.2017.11.007

Table 1.

NNMT inhibitor permeability from passive transport across membranes as measured using PAMPA

Name	IC₅₀ (µM)^a	Flux (cm/s)	Permeability Classification^b
Quinoline (highly permeable)^c	ND	33.9E-06	High permeability
1-methylnicotinamide (1-MNA)	9.0	0	No permeability
1-methylquinolinium (1-MQ)	12.1	0	No permeability
1,8-diMQ	1.8	8.63702E-07	Low permeability
1,2,4,8-tetraMQ	109.2	6.98184E-07	Low permeability
5-amino-1MQ	1.2	3.01472E-06	High permeability
3-amino-6-fluoro-1MQ	1.2	1.07832E-06	Moderate permeability
7-amino-1MQ	2.6	2.05476E-06	High permeability
2,3-diamine-1MQ	2.8	3.89795E-06	High permeability

IC₅₀ values from our published SAR study[17]

BCS, Biopharmaceutics Classification System

High membrane-permeable comparator compound[51]

ND: Not determined; Quinoline is an NNMT substrate[25]