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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Adv Biol Regul. 2017 Aug 24;68:107–119. doi: 10.1016/j.jbior.2017.08.002

Figure 3. PLD protein, activity, mRNA, and miR operate in a feedback loop in cancer cells.

Figure 3

(A) There is a causal relation between certain miRs and PLD expression. (B) During starvation, PLD (a “stress protein”) rises and mediates cell invasion. This could help cells at the core of a primary solid tumor escape hypoxia and low nutrient conditions. However, with prolonged starvation, PA levels (possibly to association to trasncription factors of the PPAR family) promote expression of several miR genes, which un turn target the 3’UTR of PLD transcripts, consequently downregulating PLD translation. In this way, the PLD-led process comes to an end in prolonged starvation.