Table 3.

Random Coefficient Model (RCM) results with persistent drinking and smoking categories (N=1,333 subjects with 10,264 total observations)

	FVC in ml			FEV1 in ml			FEV1/FVC in %
	Coefficient	SE	P value	Coefficient	SE	P value	Coefficient	SE	P value
MAIN EFFECTS
Persistent Drink & Smoke categories*
Non Drinker & Non Smoker (ref)
Only Persistent Drink	121.04	63.65	0.057	−15.30	55.75	0.784	−3.68	0.78	<0.001
Only Persistent Smoke	65.79	119.84	0.583	−140.43	104.73	0.180	−5.19	1.47	<0.001
Persistent Drink & Smoke	127.51	75.51	0.091	−88.41	65.82	0.179	−4.85	0.94	<0.001
Other (Not Persistent)	52.63	51.94	0.311	−15.62	44.90	0.728	−2.04	0.64	0.001
MAIN EFFECTS + INTERACTIONS **
Persistent Drink & Smoke categories*
Non Drinker & Non Smoker (ref)
Only Persistent Drink	−27.48	84.83	0.746	−76.26	74.83	0.308	−2.67	1.23	0.031
Only Persistent Smoke	61.61	165.43	0.710	−2.35	144.11	0.987	−0.27	2.41	0.910
Persistent Drink & Smoke	−17.16	99.81	0.863	0.41	87.76	0.996	−1.14	1.46	0.432
Other (Not Persistent)	−47.93	70.98	0.499	−12.13	61.46	0.844	0.22	1.04	0.829
Only Persistent Drink X Age	6.05	2.34	0.010	2.81	1.99	0.158	−0.02	0.04	0.528
Only Persistent Smoke X Age	−0.19	4.76	0.969	−6.04	3.99	0.131	−0.19	0.07	0.009
Persistent Drink & Smoke X Age	5.82	2.90	0.045	−4.19	2.44	0.086	−0.15	0.04	0.001
Other (Not Persistent) X Age	3.69	1.82	0.043	−0.39	1.56	0.802	−0.08	0.03	0.003

^*Adjusted for sex, age, height, pack-years, BMI categories, education categories

^**Age was centered at 21 years, so in these models main effects refer to associations of drinking and/or smoking categories with lung function at age 21 years