Table 2.
Measured sleep variables for 19 neonates with myelomeningocele and their age-matched controls1
| Myelomeningocele patients (n=19) | Control patients (n=19) | p-value | |
|---|---|---|---|
|
| |||
| Apnea Hypopnea Index (AHI) * | 34.2 ± 21.9 | 19.3 ± 11.1 | 0.021 |
| Active sleep AHI * | 52.2 ± 28.0 | 30.5 ± 19.2 | 0.015 |
| Quiet sleep AHI* | 27.0 ± 30.0 | 10.5 ± 8.1 | 0.015 |
|
| |||
| AHI Ranges (# of subjects per group) | |||
| 3 to <5 | 2 | 1 | |
| 5 to <10 | 1 | 3 | |
| 10 to <20 | 0 | 7 | |
| 20 to <30 | 7 | 2 | |
| 30 to <40 | 4 | 6 | |
| 40 to <50 | 2 | 0 | |
| >50 | 3 | 0 | |
|
| |||
| Obstructive apnea index | 3.0 ± 3.5 | 2.5 ± 2.5 | 0.74 |
|
| |||
| Central apnea index | 10.0 ± 17.2 | 4.4 ± 3.4 | 0.26 |
|
| |||
| Hypopnea index * | 21.2 ± 14.3 | 12.4 ± 7.8 | 0.044 |
|
| |||
| Apneic events > 10 seconds (Median, IQR) | 8 (3,26) | 12 (7,20) | |
|
| |||
| Apneic events > 20 seconds (Median, IQR) | 0 (0,0) | 0.5 (0,1) | |
|
| |||
| Mean oxygen saturation (%)* | 94.4 ± 2.6 | 96.3 ± 2.2 | 0.020 |
|
| |||
| Minimum oxygen saturation (%) | 82 ± 5.4 | 80.5 ± 6.4 | 0.22 |
|
| |||
| Percent of time spent with oxygen saturation < 90% | 11.5 ± 12.3 | 6.2 ± 12.5 | 0.13 |
|
| |||
| Percent of time spent in: | |||
| Active sleep* | 41.7 ± 6.7 | 47.1 ± 8.3 | 0.013 |
| Quiet sleep | 41.5 ± 10.3 | 35.2 ± 9.5 | 0.080 |
| Intermediate sleep | 16.8 ± 6.8 | 17.7 ± 8.5 | 0.58 |
1
Data are presented as mean ± standard deviation unless otherwise indicated
*
Statistically significant differences via Mann–Whitney–Wilcoxon test.