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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Arthritis Rheumatol. 2018 Jan 23;70(3):468–474. doi: 10.1002/art.40372

Figure 1.

Figure 1

Neutrophils treated with procainamide (Pro) and hydralazine (Hyd) undergo neutrophil extracellular trap (NET) formation. A, Quantification of NET formation after treatment with drugs. B, Fluorescence microscopy of NETs induced by the drugs after 4 hour incubation. C, Quantification of NET degradation after exposure with 1% serum from healthy donors. NETs were identified as extracellular structures positive for both MPO (red) and DNA (blue). Results in A and B are representative of 6 independent experiments. Results in C are representative of 5 independent experiments. **** = P < 0.0001 by Kruskal-Wallis test with Dunn’s post hoc test or Mann-Whitney U test. DPI = diphenyleneiodonium chloride; IO = calcium ionophore (A23187); Cl-am = Cl-amidine.