Procainamide and hydralazine induce NETs comprised of distinct proteins. A–C, Differences in NET protein cargo (granular, nuclear, cytosolic and cytoskeletal) in neutrophils from healthy controls (n=5), patients with ANCA-associated vasculitis (AAV) (n=4), and patients with systemic lupus erythematosus (SLE) (n=4) exposed to lipopolysaccharide (LPS), procainamide (Proc), Hydralazine (Hyd), or no additional stimuli (none). * = P < 0.05; ** = P < 0.01; *** = P < 0.001; **** = P < 0.0001 by two-way analysis of variance test. A p<0.002 defines statistical significance per Bonferroni correction for multiple comparisons.