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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Neural Transm (Vienna). 2017 Nov 10;125(3):401–417. doi: 10.1007/s00702-017-1803-y

Fig 5. Cognitive impairment in HD NHPs.

Fig 5

(a) At 16 months, HD NHPs showed more barrier reaches than control NHPs on an object retrieval detour task. (b) At 16 months, HD NHPs also showed an increase in the number of preservative reaches on the same task. (c-d) HD NHPs increased in latency on a visuomotor task at 36 months (d), but not at 8 months (c) compared to control NHPs. rHD1 carried exon 1 of the human HTT gene regulated by human polyubiquitin-C promoter, which expressed N-terminal 67 amino acids with 29 polyQ repeats. rHD7 carried exons 1-10 of the human HTT gene coding N-terminal 508 amino acids with approximately 67-72Q under the control of the human HTT promoter. (Chan et al. 2015).