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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: J AAPOS. 2017 Dec 20;22(1):32–37. doi: 10.1016/j.jaapos.2017.09.005

Table 3.

Comparison of grading results from paired gradings stratified by adjudication status for referral-warranted retinopathy of prematurity (RW-ROP)

RW-ROP grading stratified by adjudication statusa Clinical exam positive for RW-ROP Clinical exam negative for RW-ROP
No. Grading positive Sensitivity (95% CI) No. Grading negative Specificity (95% CI)
Images graded by readers 1 and 2
 Not adjudicated Agreed results 119 78 0.66 (0.5–0.76) 750 660 0.88 (0.8–0.91)
 Adjudicated Results from reader 1 83 59 0.71 (0.5–0.81) 181 89 0.49 (0.4–0.58)
Results from reader 2 83 65 0.78 (0.6–0.86) 181 63 0.35 (0.2–0.44)
Results from final grading 83 64 0.77 (0.6–0.85) 181 86 0.48 (0.3–0.57)
P value 0.48 0.11
Images graded by readers 1 and 3
 Not adjudicated Agreed results 183 148 0.81 (0.7–0.87) 2969 2705 0.91 (0.8–0.93)
 Adjudicated Results from reader 1 197 153 0.78 (0.6–0.85) 673 206 0.31 (0.2–0.35)
Results from reader 3 197 163 0.83 (0.7–0.88) 673 323 0.48 (0.4–0.53)
Results from final grading 197 167 0.85 (0.7–0.90) 673 320 0.48 (0.4–0.52)
P value 0.10 <0.001
Images graded by readers 2 and 3
 Not adjudicated Agreed results 122 100 0.82 (0.7–0.89) 1931 1811 0.94 (0.9–0.95)
 Adjudicated Results from reader 2 110 73 0.66 (0.5–0.75) 479 209 0.44 (0.3–0.49)
Results from reader 3 110 100 0.91 (0.8–0.95) 479 166 0.35 (0.3–0.40)
Results from final grading 110 94 0.85 (0.7–0.91) 479 223 0.47 (0.4–0.52)
P value 0.003 <0.001
a

Not adjudicated = image sets requiring no adjudication because two readers agreed on their grading results; adjudicated = image sets required adjudication for discrepant gradings between two readers.