UMMD treatment suppresses the melanoma growth and prolongs survival. (A–B) The volume of melanoma tumors was gradually increased in PBS injected control mice until day 12 and started to increase exponentially from day 12. However, UMMD treatment performed at days 7, 8, 9, 11 and 13 significantly suppressed the melanoma growth resulting in delayed euthanizing criteria. Arrows indicate the days of treatment, either PBS or UMMD. Statistical significance was set at p < 0.05 and error bars represent sample variations (n=7–13).