(A). Plasma PAGN concentration vs. baseline serum creatinine according to maximum infusion rate of OPA. (B). PAGN renal clearance vs. creatinine clearance. (C). Relationship of urinary PAGN clearance to plasma PAGN concentration. Data are shown for patients with “normal” and “impaired renal function” as defined in Methods.
(ORN, ornithine; PA, phenylacetate; PAGN, phenylacetylglutamine).