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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Differentiation. 2017 Dec 15;99:51–61. doi: 10.1016/j.diff.2017.12.003

Fig. 7.

Fig. 7

Loss of ITCH is protective in ApcMin/+-induced tumorigenesis. Polyps from the small intestine of 15 week-old Itch+/+; Apc+/+ (n = 11), Itcha18H/a18H; Apc+/+ (n = 11), Itch+/+; ApcMin/+ (n = 11), and Itcha18H/a18H; ApcMin/+ (n = 11) animals were visualized by staining the flushed and fixed small intestine with 0.1% methylene blue. Polyps from the entire length of the intestine were counted under a dissecting microscope. The graph shown here depicts the average number of small intestinal polyps per animal. Itcha18H/a18H; ApcMin/+ animals were observed to have a significant reduction in tumor burden compared to Itch+/+; ApcMin/+ littermates (*p < 0.001, NS = not significant). Error bars represent SD.