Table 2.
Medical management prior to extracorporeal membrane oxygenation
| Pre-ECMO team period (n = 70) | Post-ECMO team period (n = 46) | P value | |
|---|---|---|---|
| Duration of MV before ECMO, days | 2 (0–6) | 2 (0–7) | 0.510 |
| Pre-ECMO ventilator settingsa | |||
| PaO2/FiO2 | 71.5 (56.0–96.5) | 91.8 (68.3–114.3) | 0.033 |
| FiO2 (%) | 100 (100–100) | 100 (70–100) | 0.009 |
| PEEP (cmH2O) | 10 (5–12) | 10 (5–12) | 0.239 |
| Peak inspiratory pressure (cmH2O) | 30 (24–34) | 28 (23–31) | 0.402 |
| Minute volume (L) | 9.1 (6.8–11.2) | 9.5 (8.2–11.9) | 0.420 |
| VT/PBW (mL/kg) | 6.8 (5.1–8.0) | 6.8 (5.9–8.6) | 0.710 |
| Pre-ECMO treatment | |||
| Steroid | 46 (65.7) | 19 (41.3) | 0.010 |
| Neuromuscular blocking agent | 35 (50.0) | 26 (56.5) | 0.491 |
| Inhaled nitric oxide | 8 (11.4) | 12 (26.1) | 0.041 |
| Prone position | 4 (5.7) | 10 (21.7) | 0.010 |
| Vasopressor infusion | 44 (62.9) | 29 (63.0) | 0.984 |
| Pre-ECMO blood gas | |||
| pH | 7.26 (7.13–7.38) | 7.22 (7.09–7.35) | 0.333 |
| PaCO2 (mmHg) | 58.1 (45.8–73.5) | 57.8 (44.7–68.5) | 0.699 |
| PaO2 (mmHg) | 61.4 (55.0–74.2) | 64.2 (54.8–84.5) | 0.726 |
| HCO3 (mmol/L) | 25.8 (21.8–30.2) | 23.2 (19.2–28.2) | 0.063 |
| SaO2 (%) | 89.4 (85.6–92.1) | 89.4 (82.6–94.5) | 0.890 |
| Lactate before ECMO (mmol/L) | 2.26 (1.53–4.80) | 2.10 (1.60–5.11) | 0.948 |
Values are given as the median (interquartile range) or n (%)
ECMO extracorporeal membrane oxygenation, FiO2 fraction of inspired oxygen, MV mechanical ventilation, PaCO2 partial pressure of carbon dioxide in arterial blood, PaO2 partial pressure of oxygen in arterial blood, PBW predicted body weight, PEEP positive end-expiratory pressure, SaO2 arterial oxygen saturations, VT tidal volume
aData were available for 104 patients (66 patients in the pre-ECMO team period and 40 patients in the post-ECMO team period)