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. 2018 Feb 26;8:3581. doi: 10.1038/s41598-018-22067-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative phase-contrast and fluorescence microscopy photomicrographs of human fibroblast-like synoviocyte primary cultures. (a,b) Phase-contrast microscopy. (c,d) Wheat Germ Agglutinin (WGA; green) immunofluorescence labeling with 4′,6-diamidino-2-phenylindole (DAPI; blue) counterstain for nuclei. (a–d) Note the presence of either fibroblasts (Fb) or telocytes (TC), the latter being characterized by a small cell body and very long and thin moniliform processes (telopodes, Tp) often establishing intercellular contacts with fibroblasts or other telocytes (arrowheads). (e,f) Immunofluorescence labeling for CD34 (red) with DAPI (blue) counterstain for nuclei. CD34-positive cells projecting very long and thin moniliform cytoplasmic processes (telopodes, Tp) are unequivocally identifiable as telocytes (TC). The inset in (e) shows a higher magnification of a typical telopode formed by an alternation of thin segments (podomers) and expanded parts (podoms). Note the telopode of a telocyte contacting the cell body of another telocyte (arrowhead in e). Scale bar: 50 µm (a–f).