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. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — VIRMA affects cellular functions. a, b Effects of depletion of VIRMA (a) and METTL3, METTL14, and WTAP (b) by siRNA knockdowns on the profiles of m⁶A peak density along mRNA transcript. c Effect of partial VIRMA knockout (VIRMA^mut/−) on the profiles of m⁶A peak density along mRNA transcript. d Differentially expressed genes (fold change > 2) were identified by the RNA-seq in between VIRMA^mut/− and control cell lines. The number of overlapped upregulated and downregulated genes are shown. e Gene ontology (GO) and enrichment analysis of the differentially expressed and m⁶A-containing genes. f Estimate of VIRMA depletion on cell proliferation by MTS assay. Data are represented as means ± SEM of n = 3