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. 2018 Feb 26;8:3609. doi: 10.1038/s41598-018-21517-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distinct differences in the miRNAs between RC-MVs and GC-MVs. (A) Different miRNAs patterns were identified from PCR-array between two maturation status of chondrocytes, both in MVs and the parent cells. (B) Principal component analysis (PCA) of the miRNA PCR-array data for all the four different types of samples: RC-MVs, RC-cells, GC-MVs and GC-cells. The differences among these samples were clear, as larger difference showed on the x-axis direction compared to that on the y-axis. This suggests that the differences between MVs and cells were larger than between two different cell maturation stages. (C) Left panel: miRNAs in RC-MVs and GC-MVs identified by RNA-seq were plotted. Red dots represent miRNAs with at least a 2-fold expression level increase in GC-MVs than in RC-MVs. Green dots represent miRNAs with a more than 2-fold expression level increase in RC-MVs than in GC-MVs. Blue indicates the overlap between these two groups. A large number of miRNAs were differentially expressed between RC-MVs and GC-MVs. Right panel: similar comparison was done between RC-cells and GC-cells. Interestingly, the difference between RC-cells and GC-cells was not as large as that was seen between RC-MVs and GC-MVs.