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. 2018 Feb 22;9:43. doi: 10.3389/fpsyt.2018.00043

Figure 4.

Figure 4

Other parameters from the Intolerance-to-Delay Task. (A) Total small-and-soon (SS) trials at increasing delays. While there is a clear increase of the number of SS trials at higher delays in wild-type (WT) and dopamine transporter (DAT)–heterozygous (HET) rats, knockout (KO) rats did not show such an increase. **P < 0.0001. (B) The effect of the different drugs on the total SS trials. The administration of amphetamine (AMPH) on WT and DAT–HET rats has a significant effect to increase the total SS trials, if compared to saline, vehicle, and RO-5203648. *P < 0.05. (C) Total [SS + large-and-late (LL)] trials performed at all the three delays: total trials of KO rats were always significantly lower than those of WT and DAT–HET rats. **P < 0.0001. (D) The total inadequate nose-pokes, performed in both nose-poking holes during the timeout (i.e., when without consequences). For WT and DAT–HET rats, the total inadequate nose-pokes significantly increase at higher delays; conversely, for KO rats, inadequate nose-pokes significantly decrease at higher delays. *P < 0.05, **P < 0.0001.