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. 2018 Feb 22;9:49. doi: 10.3389/fgene.2018.00049

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Copyright © 2018 Schlaffer, Buchfelder, Stoehr, Buslei and Hölsken.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological characterization; HE staining shows a lesion of squamous couple stone differentiated epithelium. Magnification revealed a superficial cell layer harboring kinocilia (arrow) and goblet cells (white star). The following immunohistochemical stainings show the evidence and expression pattern of the mutated BRAF V600E protein, beta-catenin; the phosphorylated ERK (ERK-P) and the proliferation marker Ki-67; as well as the distribution of the cell-cell contact proteins, claudin-1 and EpCAM. In a higher resolution, EpCAM is only detectable in ciliated cells of the superficial cell layer.