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. 2017 Dec 11;98(6):329–340. doi: 10.1111/iep.12255

Figure 3.

Figure 3

Insulin sensitivity and circulating insulin levels (a) Intraperitoneal insulin tolerance test (ipITT) and (b) the constant rate for glucose disappearance during ipITT (K ITT) (n = 13 for Naive, 12 for Sham, 8 for Sublethal and 8 for Lethal groups). We can observe the reduction in insulin sensitivity according to lethality degree in the CLP groups 24 h after surgery. (c) Fasting insulin values were significantly higher in the Lethal group with a tendency to increase in the Sublethal group (n = 3 for Naive, 5 for Sham, 8 for Sublethal and 8 for Lethal groups). (d) Circulating TNF‐α levels in fasted mice were significantly higher in the Sublethal group with a tendency to also increase in the Lethal group 24 h after CLP (n = 5 for all groups). Results are expressed as mean ± SEM in ‘a, b’ graphs and as median and interquartiles in ‘c, d’ graphs. *significantly different vs. Naive group and #significantly different vs. Sham group using anova with Tukey's post hoc test for ‘a, b’ data or Kruskal–Wallis with Dunn's post hoc test for ‘c, d’ data. P < 0.05. +means that unpaired Mann–Whitney test was applied for comparison of the Sublethal in ‘c’ data and the Lethal in ‘d’ data with the Sham group respectively.