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. 2018 Feb 26;9:816. doi: 10.1038/s41467-018-03105-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Pharmacologic inhibition of the amphiregulin receptor ErbB1 during murine myocardial ischemia–reperfusion injury. a–c Mice underwent 60 min of myocardial ischemia, followed by 120 min of reperfusion; infarct sizes were measured by double staining with Evan’s blue and triphenyltetrazolium chloride and serum samples were collected. All infarct sizes are presented as the percentage of infarcted tissue in relation to the area-at-risk. Serum Troponin levels were determined by ELISA. a Infarct sizes of C57/BL6 mice after 60 min of ischemia and 120 min reperfusion, treated prior to myocardial ischemia reperfusion with vehicle or an ERBB1-specific inhibitor (AG1478), administered 15 min prior to ischemia via an indwelling arterial catheter. Data presented as the percentage of infarcted area in relation to area-at-risk (n = 4 per group). b Representative infarct staining of C57/BL6 treated with vehicle or AG1478. c Troponin serum levels of C57/BL6 mice, after 60 min ischemia, 120 min reperfusion, treated with vehicle or AG1478 (n = 5 per group). d Infarct sizes of C57/BL6 mice after 60 min of ischemia and 120 min reperfusion, treated 15 min prior to ischemia via an indwelling arterial catheter with vehicle or a highly specific ERBB1-specific inhibitor (Cetuximab). Data presented as the percentage of infarcted area in relation to area-at-risk (control n = 4; cetuximab n = 8). e Representative infarct staining of C57/BL6 treated with vehicle or Cetuximab. f Troponin serum levels of C57/BL6 mice after 60 min ischemia, 120 min reperfusion, treated with vehicle or Cetuximab (n = 7 per group). All data in this figure is presented as mean ± SD. Statistical significance assessed by two-sided, unpaired Student’s t-test