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. 2018 Feb 26;8:3594. doi: 10.1038/s41598-018-21945-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of two-node networks for decoding AM and FM input signals. (A) Input signals with two different transcription factor dynamics, whose strengths has equal total area under the input curves. (B) Steady-state expression level of the target gene for two-node network with positive regulation. It is plotted as a function of log(K) with n = 4 for FM input (yellow) and AM input (green), respectively. (C) Same as in (B), but with negative regulation.