Fig. 2.

Oral fat loading test after treatment with K-877 and fenofibrate.

At twelve weeks of age, the OFL test was performed using olive oil by gavage (17 µL/g body weight) after an overnight fast. Blood (50 µL) was drawn from an orbital vein, and plasma levels of TGs (A, B), FFA (C, D), TC (E,F) and HDL-cholesterol (HDL-C) (G) were measured, and these levels were compared on the basis of incremental AUC. Lipoprotein lipase (LPL) activities were compared among the three groups during the fasting state. *: p < 0.05, **: p < 0.01 compared with HFD only.