Table 1. Exclusion criteria applies to screen data.

Exclusion categories for mice	Wildtypes	Mutants	Comment
The exclusion criteria, genotype group it can be applied to and reasoning is indicated.
Excluded (difficulty dosing)	x	x	This is when a comment was made at the time of dosing that there were some difficulties in ensuring the full dose (0.1 ml) was administered into the vein
Excluded (count=0 so presumed failed dosing)	x	x	This is when there were no mets present, and we know that is impossible for a WT (and highly improbable for a mutant)
Excluded (count ≤35 so presumed failed dosing)	x		This is when there were less than or equal to 35 mets present, and we know from historical WT data that indicates that the full dose was not administered
Excluded (pathology present at time of necropsy)	x	x	This is when the mouse was found to have some abnormality at the time of necropsy (not present or observable at the time of dosing) that may have an impact on the met count (examples include malocclusion, enlargment of an internal organ, scratching, fight wounds)