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. 2018 Feb 22;9:236. doi: 10.3389/fimmu.2018.00236

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Copyright © 2018 Westman, Chakrakodi, Snäll, Mörgelin, Bruun Madsen, Hyldegaard, Neumann, Frick, Norrby-Teglund, Björck and Herwald.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Streptococcal inhibitor of complement (SIC) expression and colocalization with histone H4 in patients with necrotizing soft-tissue infection. Snap-frozen biopsies from patients with infections caused by M1 (A,B) S. pyogenes strains were analyzed for SIC (red) and histone H4 (green) expression. DNA is stained with DAPI (blue). A biopsy from a healthy donor was used as a control (C). To confirm colocalization of the two markers, vertical planes of the indicated areas are shown, demonstrating colocalization in (A,B). Scale bar 20 µm.