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. 2018 Feb 22;9:25. doi: 10.3389/fgene.2018.00025

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Copyright © 2018 Skare, Lie, Haaland, Gjerdevik, Romanowska, Gjessing and Jugessur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Statistical power for a single SNP. (A) Shows the simulated power for the model restricted to girls only, (B) shows the simulated power for the model without X-inactivation, and (C) shows the simulated power for the model with X-inactivation. The figures on the left depict the power with increasing relative risk ratios (RRRs) (increasing values of RR_m; RR_f = 1) and differing sample sizes of case-parent triads, using a fixed minor allele frequency (MAF) of 0.2. The figures on the right-hand side show the power with varying RRRs and MAFs, assuming a total of 300 case-parent triads for the girls-only analyses in (A) and 600 case-parent triads in (B,C) (assuming an equal distribution of boys and girls). We used a nominal significance level of 0.05 throughout.