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. 2018 Jan 11;9(1):e3178. doi: 10.1038/cddis.2017.367

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Copyright © 2018 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mild doses of FV-429 enhanced paclitaxel-induced G2/M phase arrest under hypoxia. (a) The influence of FV-429 on cell growth inhibition assessed by MTT assay. Data had been statistically analyzed by Microsoft Excel 2013 and expressed as means±S.D. for three independent experiments. (b) Percentage of non-apoptotic cells induced by 5, 10 and 20 μM FV-429 detected by Annexin V/PI double staining assay. Data had been statistically analyzed by Microsoft Excel 2013 and expressed as means±S.D. for three independent experiments. (c) The influence of FV-429 on cell growth inhibition of paclitaxel under hypoxia assessed by MTT assay. Data had been statistically analyzed by Microsoft Excel 2013 and expressed as means±S.D. for three independent experiments. (d) The influence of FV-429 on cell cycle with paclitaxel treatment under hypoxia. Summary of the percentage of cells at G0/G1, S and G2/M phase was performed. (e) The influence of FV-429 on the expression of cylin B1, p-cdc25c, cdc25c, p-CDK1 and CDK1 with paclitaxel treatment under hypoxia. Protein expression change was represented by densitometric analysis. The results are representative of three independent experiments and expressed as means±S.D., **P<0.01, compared with normoxia control groups and ^##P<0.01, compared with the hypoxia control groups