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. 2018 Jan 11;9(1):e3178. doi: 10.1038/cddis.2017.367

Figure 4.

Figure 4

FV-429 suppressed c-Src/Stat3/HIF-1α pathway and c-Src mRNA expression. (a) The influence of FV-429 on p-Src (Tyr 416), c-Src, p-Stat3 (Tyr 705), Stat3 and HIF-1α expression with paclitaxel treatment under hypoxia. Protein expression change was represented by densitometric analysis. The results are representative of three independent experiments and expressed as means±S.D., **P<0.01, compared with normoxia control groups and ##P<0.01, compared with the hypoxia control groups. (b) The influence of FV-429 on mRNA expression of CSK, STAT3 and HIF-1α detected by electrophoresis on 3% agarose gel. RNA expression change was represented by densitometric analysis. The results are representative of three independent experiments and expressed as means±S.D., **P<0.01, compared with normoxia control groups and ##P<0.01, compared with the hypoxia control groups. (c) The influence of FV-429 on mRNA expression of CSK, STAT3 and HIF-1α detected by reverse transcriptase PCR. Data had been statistically analyzed and displayed in column charts as means±S.D. for three independent experiments by Graphpad Prism 6.0c, **P<0.01, compared with the normoxia control groups and ##P<0.01, compared with the hypoxia control groups