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. 2018 Jan 11;9(1):e3178. doi: 10.1038/cddis.2017.367

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Copyright © 2018 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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FV-429 inhibited Stat3 nuclear translocation and binding to HIF-1α. (a) The influence of FV-429 on nuclear expression of Stat3 and total expression of HIF-1α under hypoxia. Protein expression change was represented by densitometric analysis. The results are representative of three independent experiments and expressed as means±S.D., **P<0.01, compared with the normoxia control groups and ^##P<0.01, compared with the hypoxia control groups. (b) The influence of FV-429 on Stat3 nuclear translocation examined by immunofluorescence (× 600). (c) The influence of FV-429 on binding ability of Stat3 to HIF-1α under hypoxia assessed by EMSA