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. 2017 Dec 7;8(12):e3175. doi: 10.1038/cddis.2017.392

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Gestational metformin exposure reduces fetal bodyweight. (a) Maternal blood glucose on gestational day 18.5 showing no significant difference between the groups. Control group, n(dams)=5; metformin group, n(dams)=7. NS, not statistically significant. (b) Scatter plots of litter size, with each dot representing a dam. The horizontal line depicts group median and the whiskers mark the interquartile range. (c) Scatter plots of fetal bodyweight at E18.5, with each dot represents a fetus. Control group, n (fetuses from 5 dams)=48; metformin group, n(fetuses from 7 dams)=63. P-value indicates statistically significant