Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 3;7(1):bio026187. doi: 10.1242/bio.026187

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Fig. 6. — Schematic representation of multiple signaling pathways activated by insulin leading to monocyte/macrophage chemotaxis. Insulin stimulates THP-1 cell chemotaxis in an insulin-receptor-dependent manner. PI3K-Akt, SPAK/JNK, and p38 MAPK are signal pathways that are involved in insulin-induced THP-1 cell chemotaxis. Rac1 is an important molecule in regulating cell motility. Both PI3K-Akt and SPAK/JNK signaling are involved in Rac1 activation.