FIG 6.

Antitumor activity of R-317. (A to C) Groups of 5 mice from the hHER2-transgenic C56BL6 strain were implanted with hHER2-LLC-1 cells in the left flank. Starting 3 days later, mice received four intratumoral treatments (1 × 10E8 PFU/treatment) at 3 to 4 days' intervals with R-317 alone and with R-LM113 and R-87 as controls. Tumor volumes and the number of tumor-free animals for each treatment group are shown. (D) Distribution of the tumor size at 28 days after the initial treatment. Statistical significance was calculated using the t test: *, P < 0.05; **, P < 0.01; ***, P < 0.001. This experiment is the same as that shown in Fig. 7 of the companion paper (37).