FIG 6.
IRE1α inhibition increases the oncolytic effects of the M1 virus in vivo. (A) Survival of tumor-bearing mice after treatment with STF083010, the M1 virus, or both. A U87 orthotopic glioma model was established, and mice were pretreated or not with STF083010 (20 mg/kg/day) 7 times through intraperitoneal injection 1 week after tumor inoculation. Mice were also treated or not with the M1 virus (2 × 107 PFU) 6 times through tail vein injections 1 week after tumor inoculation. (B) Expression of cleaved caspase-3 and Ki67 in orthotopic glioma tissue. Tissues derived from U87 orthotopic glioma model mice after treatment for 3 days are shown. (C) Quantification of data from panel B. **, P < 0.01.