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. 2018 Feb 26;92(6):e02110-17. doi: 10.1128/JVI.02110-17

FIG 3.

FIG 3

Entinostat induces more Nef-dependent downmodulation of MHC-I than pan-HDIs. (a) Representative flow cytometric analysis of MHC-I downmodulation on latently infected HSPCs treated with the indicated LRAs. The magnitude of MHC-I downmodulation in HSPCs with induced viral gene expression was calculated by dividing the MHC-I median fluorescence intensity (MedFI) of the E-GFPneg population by that of the E-GFPpos population for each sample (E-GFPnegMHC-I MedFI/E-GFPposMHC-I MedFI). (b) Summary graph of fold MHC-I downmodulation. Data are presented relative to DMSO (means ± SEM, n ≥ 4). P values were calculated by two-tailed, unpaired Student's t test. *, P < 0.05; ***, P < 0.001. Asterisks above each condition indicate statistically significant differences compared to DMSO. Solid bar indicates statistically significant differences between groups subjected to different conditions.