FIG 5.

Entinostat plus bryostatin-1 induces maximum viral outgrowth from latently infected cells, whereas pan-HDIs are inhibitory when added in combination. Summary graph of genomic HIV mRNA copies/ml measured in supernatants from cultures of latently infected HSPCs treated as described for Fig. 4. Viral outgrowth observed with spontaneous reactivation under DMSO solvent conditions was subtracted from each experiment. Data are presented as a percentage of the effect of TNF-α (means ± SEM, n ≥ 4). P values were calculated by two-tailed, unpaired Student's t test. ****, P < 0.0001.