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Vorinostat inhibits cellular factors important for robust HIV gene expression. (a) Summary graph showing abundance of activated NF-κB/p65 in PBMCs treated for 24 h with indicated LRAs. Data were normalized to the effect of bryostatin-1 (means ± SEM, n ≥ 4). Immunoblot analysis of whole-cell lysates from HSPCs (b) and PBMCs (c) treated for 24 h with indicated LRAs. P values were calculated by two-tailed, unpaired Student's t test. *, P < 0.05; **, P < 0.01.
