FIGURE 6.

Function of recoded cystic fibrosis transmembrane conductance regulator (CFTR) channels. a) Representative recordings obtained from HEK293 cells expressing the indicated construct (mock or CFTR-WT) before and after addition of iodide-containing PBS (injection indicated with an arrow), and with and without the CFTR potentiator VX770. b) Transport rates measured under basal conditions and in the presence of the CFTR potentiator VX770. ^#: significant difference compared with wild-type control conditions (p<0.01, ANOVA followed by a Fisher test); ^¶: significant effect of VX770 (p<0.01, unpaired t-test); ns: nonsignificant effect of VX770.