Table 2.

Inhibition of GLIC WT and mutants by neurosteroids

	Average % effect	S.E.	n	Average DMSO-corrected % effect	S.E.
WT
Allopregnanolone	−17	2	9	−10	2
5α-6-AziP	−25	2	5	−18	2
5α-12-AziP	−27	2	6	−20	2
5α-15-AziP	−18	2	5	−11	2
KK200	−93	1	5	−86	2
CW12	−15	1	5	−8	1
I271W
Allopregnanolone	−18	1	6	−8	1
5α-6-AziP	−30	6	5	−20	6
KK200	−17	2	5	−7	2
F121A
Allopregnanolone	−10	1	8	13	3
5α-6-AziP	14	4	6	37	5
KK200	−23	4	5	0	5
Y254A
Allopregnanolone	−13	1	9	12	2
5α-6-AziP	−27	2	5	−2	3
KK200	−34	2	4	−9	3