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Subcellular localization of human NLRP11 and its role in inflammasome formation. A, indirect immunofluorescence micrograph of HeLa cells transiently transfected for about 24 h with myc-NLRP3, myc-NLRP11, and HA-ASC (as indicated). Scale bars = 10 μm. B, caspase-1 activation assay (iGLuc) in HEK293T cells expressing caspase-1 and ASC (10 ng each) together with the indicted protein. Standard deviation of three experiments conducted in triplicates is shown. *, p < 0.05; **, p < 0.005.
