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. 2018 Feb 19;9:250. doi: 10.3389/fimmu.2018.00250

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Copyright © 2018 Ezzelarab, Lu, Shufesky, Morelli and Thomson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Upregulation of cytotoxic T-lymphocyte-associated antigen (Ag) 4 (CTLA4) and PD1 expression correlates with augmented regulatory T cells (Treg) phenotype by allo-stimulated rhesus CD4⁺ T cells. (A) The percentages of proliferating and non-proliferating CD4⁺ T cells expressing the Treg phenotype, CD25^hi, Foxp3^hi, and CD127^lo, as well as CTLA4 and PD1 were evaluated in carboxyfluorescein succinimidyl ester (CFSE)-mixed leukocyte reaction. Responder peripheral blood mononuclear cells (PBMC) were co-cultured with allogeneic, T cell-depleted PBMC for 5 days. (B) Combined data from four individual monkeys are shown. Values are means + 1SD. *p < 0.05; only significant values are shown.