Table 1.
Classification of HEV genotypes and subtypes in relation to the virus hosts and disease development.
| Genus | Species | Genotype | Proposed subtypes and reference sequence (Accession No.) | Natural hosts | Infectious to humans (Reference) | Reference of human infection | Chronic infection in immunocompromised person |
|---|---|---|---|---|---|---|---|
| Orthohepevirus | Orthohepevirus A | 1 | 1a(M73218) | Human | Yes | Tsarev et al., 1992 | No |
| 1b(D11092) | |||||||
| 1c(X98292) | |||||||
| 1d(AY230202) | |||||||
| 1e(AY204877) | |||||||
| 1f(JF443721) | |||||||
| 2 | 2a(M74506) | Human | Yes | Reyes et al., 1991; Chatterjee et al., 1997 | No | ||
| 2b(only partial sequence,AY903950)1 | |||||||
| 3 | 3a(AF082843) | Human, pig, rabbit, deer, mongoose, wild boar | Yes | Kwo et al., 1997; Meng et al., 1997; Schlauder et al., 1998 | Yes | ||
| 3b(AP003430) | |||||||
| 3c(FJ705359) | |||||||
| 3d(only partial sequence, AF296165-7) | |||||||
| 3e(AB248521) | |||||||
| 3f(AB369687) | |||||||
| 3g(AF455784) | |||||||
| 3h(JQ013794) | |||||||
| 3i(FJ998008) | |||||||
| 3j(AY115488) | |||||||
| 4 | 4a(AB197673) | Human, pig, yak, wild boar | Yes | Wang et al., 1999, 2000; Nishizawa et al., 2003 | Yes | ||
| 4b(DQ279091) | |||||||
| 4c(AB074915) | |||||||
| 4d(AJ272108) | |||||||
| 4e(AY723745) | |||||||
| 4f(AB220974) | |||||||
| 4g(AB108537) | |||||||
| 4h(GU119961) | |||||||
| 4i(DQ450072) | |||||||
| 5 | 5a(AB573435) | Wild boar | Not Reported | Not Reported | N/A | ||
| 6 | 6a(AB602441) | Wild boar | Not Reported | Not Reported | N/A | ||
| 7 | 7a(KJ496143) | Camel | Yes | Lee et al., 2016 | Yes | ||
| 8 | N/A2 | Camel | Not Reported | Not Reported | N/A | ||
| Orthohepevirus C | C1 | N/A | Rat | Unlikely based on non-human primate data | Not Reported | N/A | |
| C2 | N/A | Ferret | Unlikely based on non-human primate data | Not Reported | N/A | ||
| Orthohepevirus D | N/A | N/A | Bat | Not Reported | Not Reported | N/A |
1There is no complete genome sequence available for corresponding GenBank accession number. 2Data for corresponding information is not available or not yet tested according to the available literatures.