Table 1.
Manifestation of aHUS, treatment, and renal function during pregnancies in 14 women
| Patient | Onset of aHUS | Preg | Prior First Preg CKD Stage | Adverse Events | Maintenance Treatment | As of 2015 (End of Study) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Age | Treatment | During Preg | After Preg | Prior First Preg | After Preg | Age | CKD Stage | Mainten. Treatment | |||
| A.1 | 3 | supportive, PEX | 2 | CKD-G1 | 1: none, with PI | 1: none | none | 1: none | 24 | CKD-G1 | none |
| 2: proteinuria, hypertension, with PI | 2: persistent proteinuria | 2: none | |||||||||
| A.2 | 24 | none | 3 | CKD-G1T | 1: none (KTX) | 1: none | none | 1: none | 33 | CKD-G2T | none |
| 2: none (KTX) | 2: none | 2: none | |||||||||
| 3: none (IUFD gw 31) | 3: none | 3: none | |||||||||
| B.1 | 28 | PEX, ecul | 1 | unknown | 1: none | 1: none | none | 1: none | 31 | CKD-G4 | none |
| B.2 | 39 | none | 2 | unknown | 1: none | 1: none | none | 1: none | 43 | CKD-G3bT | ecul |
| 2: hypertension | 2: none | ||||||||||
| B.3 | 37 | PEX | 2 | unknown | 1: none | 1: none | none | 1: none | 41 | normal | none |
| 2: none | 2: none | ||||||||||
| B.4 | 34 | PEX | 1 | unknown | 1: none | 1: none | none | 1: none | 42 | CKD-G4T | ecul |
| B.5 | 57 | none | 2 | unknown | 1: none | 1: none | none | 1: none | 60 | CKD-G2 | none |
| 2: none | 2: none | ||||||||||
| C.1 | 20 | PEX | 3 | normal | 1: none | 1: p-aHUS | none | 1: none | 23 | CKD-G1 | none |
| 2: none, with PI | 2: none | 2: none | |||||||||
| 3: none, with PI | 3: none | 3: none | |||||||||
| C.2 | 31 | none | 3 | CKD-G3b | 1: increasing creatinine, preeclampsia, fetal death | 1: p-aHUS | none | 1: none | 53 | CKD-G5D | none |
| 2: none, spont. abortion | 2: none | 2: none | |||||||||
| 3: none, spont. abortion | 3: none | 3: none | |||||||||
| C.3 | 28 | none | 1 | CKD-G3b/4T | 1: preeclampsia gw 26 | 1: p-aHUS | none | 1: none | 42 | CKD-G5D | none |
| C.4 | 24 | PEX | 1 | normal | 1: spont. abortion | 1: p-aHUS | none | 1: none | 27 | normal | none |
| C.5 | 33 | none | 1 | normal | 1: proteinuria, HELLP | 1: p-aHUS | none | 1: none | 42 | CKD-G5D | none |
| C.6 | 19 | PEX | 3 | normal | 1: none | 1: aHUS (+12 mo) | none | 1: PI | 32 | CKD-G4T | ecul |
| 2: none, with PI (KTX) | 2: none | 2: PI | |||||||||
| 3: none, with PI (KTX) | 3: p-aHUS (+1 d) | 3: ecul | |||||||||
| C.7 | 27 | PEX | 2 | unknown | 1: none | 1: none | none | 1: none | 33 | CKD-G1T | ecul |
| 2: none | 2: p-aHUS (+6 d) | 2: PEX | |||||||||
Preg, pregnancy; mainten., maintenance; PEX, plasma exchange; PI, plasma infusion; KTX, kidney transplant; IUFD, intrauterine fetal death; gw, gestational week; ecul, eculizumab; spont., spontaneous.