Figure 11.

Administration of tTHP after IRI ameliorates injury: THP^−/− mice were treated 24 hours after IRI with THP or vehicle. (A) Serum Cr and (B) NGAL were measured at baseline and after injury. THP-treated mice had a reduction in subsequent injury compared with vehicle. (C and D) Histologic assessment at 72 hours also shows improvement of injury (assessed by necrosis [N], casts [C], and dilation [D]). (E) This was quantitated using an injury scoring system. (D) NGAL mRNA after THP- or vehicle-treated mice. (F) Quantitative analysis of CD206⁺ cells (mean±SEM per kidney cross-section), and (G) representative images of CD206 immunohistochemitry. The insets are enlarged views of the areas marked within the boxes. Asterisk denotes statistical significance (P<0.05) between the two groups. n=7–8 per group. Serum Cr, creatinine.