Figure 4.

The interactome of TG2 in UUO and sham control kidney reveals increased interactivity of TG2 with proteins related to vesicular trafficking, cytoskeleton, and ECM dynamics in the UUO model. The protein interaction network built from TG2-associated proteins in (A) UUO and (B) sham-operated kidney membranes was mapped against the M. musculus reference database using String V10.0 (http://string-db.org). Candidates were selected using both known and predicted protein interactions and a threshold confidence level of 0.4 (default). Networks were imported in Cytoscape and color coded according to the main functional nodes. The thickness of the lines is proportional to the confidence of the interactions.