Table 1.
Baseline urine and serum electrolyte profile of CHIP−/−and CHIPM247/M247 mice
| Parameter | CHIP+/+ | CHIP−/− | P Value | CHIPT247/T247 | CHIPM247/M247 | P Value |
|---|---|---|---|---|---|---|
| Plasma | ||||||
| Osmolality, mOsm/kg H2O | 374±8 | 370±4 | ns | 375±6 | 369±3 | ns |
| Na+, mmol/L | 147±0.5 | 146±0.5 | ns | 147±1 | 145±0.5 | ns |
| K+, mmol/L | 4.92±0.17 | 4.76±0.39 | ns | 4.85±0.26 | 4.65±0.29 | ns |
| Cl−, mmol/L | 114±1 | 114±0.5 | ns | 114±2 | 113±1 | ns |
| Urea, mmol/L | 10.6±0.6 | 10.4±0.4 | ns | 8.6±0.3 | 8.0±0.5 | ns |
| Urine | ||||||
| Na+, mmol/L | 70±11 | 97±5 | <0.05 | 67±7 | 93±8 | <0.05 |
| Na+-to-creatinine ratio | 24±2 | 28±3 | ns | 27±4 | 27±3 | ns |
| K+, mmol/L | 94±11 | 141±8 | <0.01 | 110±9 | 145±9 | <0.05 |
| K+-to-creatinine ratio | 34±4 | 38±3 | ns | 38±2 | 39±2 | ns |
| Cl−, mmol/L | 145±26 | 202±5 | <0.05 | 154±14 | 194±17 | ns |
| Cl−-to-creatinine ratio | 50±5 | 55±4 | ns | 56±6 | 54±5 | ns |
| Urea, mmol/L | 990±91 | 1349±112 | <0.05 | 960±60 | 1313±79 | <0.01 |
| Urea-to-creatinine ratio | 354±31 | 354±18 | ns | 347±24 | 351±19 | ns |
| Creatinine, mmol/L | 2.8±0.2 | 3.8±0.3 | <0.01 | 2.9±0.3 | 3.8±0.3 | <0.05 |
Na+, Sodium; K+, Potassium; Cl−, Chloride.