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. 2018 Jan 10;29(3):1049–1062. doi: 10.1681/ASN.2017060679

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Figure 5. — Tfhs-memory B cells crosstalk is altered in the presence of Belatacept. Purified blood memory B cells (CD19+IgD−CD38^dimCD27^±) were cocultured with Tfhs (CD4+CD45RA−CXCR5+PD1+) at a 1:1 ratio (1–3×10⁴) in the presence of the superantigen staphylococcal enterotoxin B (SEB) for 5 days with or without Belatacept. (A) Dot plot of ICOS in CD4+CXCR5+ cells for a representative donor with or without Belatacept or stimulation by SEB. Notably, the expressions of ICOS (left panel) and PD1 (data not shown) were negative without SEB stimulation. (B and C) Proportions of (B) ICOS+ and (C) ICOS+PD1+ Tfhs were analyzed by flow cytometry. (D) MFI of ICOS+ Tfhs. (E) Plasmablasts (CD19+CD38^hi) proportion. Data are given as mean±SEM for each group. Bela, Belatacept; w/o Bela, without Belatacept.