Figure 6.

Transcriptional profiling of human and mouse IPCs. (A) Gene-level correlation of normalized mRNA-seq reads between human (hu) IPC and NPC. (B) Gene-level correlation of normalized mRNA-seq reads between mouse (ms) IPC and NPC. (C) Immunostaining of interstitial markers in mouse and human kidneys as specified on fields. (D) Breakdown of mouse (top) or human (bottom) genes expressed in IPC or NPC by their relative expression in the two cell types. Genes enriched in one of the cell types satisfy TPM>5 and fold change >3. Other expressed genes are categorized as “non-DE.” (Middle) Pie chart shows breakdown of mouse IPC-enriched genes by their relative expression between human IPC and NPC. DE, differentially expressed enrich., enriched; norm., normalized; UB, ureteric bud epithelium; vs., versus.