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. 2018 Feb 26;9:814. doi: 10.1038/s41467-018-03036-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Metabolomics analysis of wild-type and Lkb1 mutant kidneys. Heatmap showing relative abundance of the 25 most significantly affected metabolites extracted from samples of cultured kidneys from embryonic day 13.5 wild-type and Lkb1 mutant kidneys cultured in control media (DMEM) and DMEM-glutamine. The colorbar presented is a log2 scale (a). Principal Component Analysis (PCA) of wild-type and Lkb1 mutant kidneys in the presence and absence of glutamine (b)