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. 2018 Feb 22;12:43. doi: 10.3389/fncel.2018.00043

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Copyright © 2018 Rosskothen-Kuhl, Hildebrandt, Birkenhäger and Illing.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of 1 d EIS on cells in the CIC of deafened rats. (A,B) Fos was expressed in the CIC contralateral to the simulated cochlea (B) in a population of neurons that extends beyond tonotopic boundaries known from nh animals (arrowheads). Ipsilaterally (A), only few and scattered Fos-positive neurons were present. (C,D) In a nearby section stained for GFAP, a massive growth of astrocytes was noted taking place regionally specific in the contralateral CIC where Fos-positive neurons were abundant (D, arrowheads); no such changes occurred ipsilaterally (C). (E,F) In another nearby section, microglia identified by IBA1 immunoreactivity showed a modified morphology indicating their activation in just the same region of the contralateral CIC (F, arrowheads); no such changes occurred ipsilaterally (E). Frames show positions of insets. Scale bar for major panels: 200 μm; scale bar for insets: 20 μm.